Hepatoprotective Activity of Wedelia calendulacea L. Against Acute Hepatotoxicity in Rats

The hepatoprotective activity of ethanolic extract of Wedelia calendulacea L. (Family: Asteraceae) 4 was studied against CCl induced, acute hepatotoxicity in rats. Hepatoprotective activity of the ethanolic-leaf extract of W.calendulacea (EEWC) was studied by estimating serum enzyme activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), protein and bilirubin. 4 The treatment with EEWC showed a dose-dependent reduction of CCl induced elevated serum levels of enzyme activities with parallel increase in total protein and bilirubin, indicating the extract could preserve the normal functional status of the liver. The weight of the organs such as liver, heart, lung, spleen and kidney in 4 4 CCl induced experimental animals administered with EEWC showed an increase over CCl control group.